GMPS

Across TCGA pan-cancer cohorts, GMPS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GMPS data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GMPS mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GMPS expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

COAD, CCRCC, and LUAD are the cancer types where GMPS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.884	1.000	.021	48	view →
CCRCC	OS	Tertile	All	0.533	0.948	.011	22	view →
LUAD	OS	Tertile	III,IV	0.849	0.240	.021	2	view →
HNSC	OS	Tertile	All	0.812	0.923	.034	1	view →
PDAC	OS	Median	II,III,IV	0.793	0.888	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GMPS–COAD (DFS)

Open the COAD breakdown →