GMPR2

Across TCGA pan-cancer cohorts, GMPR2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GMPR2 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GMPR2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GMPR2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where GMPR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.344	.009	20	view →
PDAC	OS	Median	All	0.623	0.457	.015	9	view →
UCEC	DFS	Quartile	III,IV	0.411	1.000	.040	8	view →
CCRCC	DFS	Median	III,IV	0.818	0.244	.031	3	view →
LSCC	DFS	Median	All	0.894	0.518	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GMPR2–HNSC (OS)

Open the HNSC breakdown →