GMPR2

Across TCGA patient cohorts, GMPR2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMPR2-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with GMPR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GMPR2-to-partner and partner-to-GMPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GMPR2-low versus GMPR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPR2→partner) and Y-score (partner→GMPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.320	-2.115	.003	.019	3	1
UCEC	A-Raf_pS299 →	-0.169	-3.321	.001	.010	3	1
UCEC	ERK2 →	+0.308	+2.700	<.001	.006	2	2
UCEC	FOXO3a_pS318_S321 →	-0.120	-1.874	.027	.049	3	1
UCEC	GATA6 →	-0.182	-2.800	.007	.003	3	1
UCEC	INPP4B →	-0.356	-1.874	.011	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

EGFR_pY1068 by GMPR2 expression — UCEC

Explore this box plot interactively →