GMPR

Across TCGA pan-cancer cohorts, GMPR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GMPR data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GMPR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GMPR expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where GMPR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.913	0.588	<.001	34	view →
COAD	DFS	Median	III,IV	0.893	1.000	.037	12	view →
LUAD	OS	Tertile	All	0.923	0.749	.029	7	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	6	view →
LSCC	OS	Median	III,IV	0.484	0.873	.015	6	view →
OV	DFS	Tertile	All	0.589	1.000	.025	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GMPR–CCRCC (DFS)

Open the CCRCC breakdown →