GMPR

Across TCGA patient cohorts, GMPR mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMPR-associated genes across cancer lineages are Rab25, ATM, and Tuberin_pT1462. Each is linked with GMPR in more than 1 cancer types. Because this analysis shows association rather than direction, both GMPR-to-partner and partner-to-GMPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by GMPR-low versus GMPR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPR→partner) and Y-score (partner→GMPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.590	-3.321	<.001	.010	3	1
UCEC	ATM →	-0.802	-2.986	<.001	.035	3	1
UCEC	Tuberin_pT1462 →	+0.244	+2.817	.044	.036	2	1
UCEC	Caspase-8 →	-0.285	-3.169	.030	.019	2	1
UCEC	Claudin-7 →	-0.645	-3.321	.014	.010	2	1
UCEC	MEK1 →	+0.620	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Rab25 by GMPR expression — UCEC

Explore this box plot interactively →