GMPR

Across TCGA cell cohorts, GMPR mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GMPR-associated genes across cancer lineages are ASB10, NPFFR1, and C16orf92. Each is linked with GMPR in more than 1 cancer types. Because this analysis shows association rather than direction, both GMPR-to-partner and partner-to-GMPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB10 grouped by GMPR-low versus GMPR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPR→partner) and Y-score (partner→GMPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASB10 →	+0.083	+3.551	<.001	.009	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+4.037	<.001	.004	3	1
BLOOD_Leukemia	C16orf92 →	+0.167	+4.037	<.001	.004	3	1
BLOOD_Leukemia	OR10K2 →	+0.053	+3.705	<.001	.007	3	1
BLOOD_Leukemia	DEFB108B →	+0.127	+4.269	<.001	.002	3	1
BLOOD_Leukemia	SLC6A17 →	+0.205	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ASB10 by GMPR expression — BLOOD_Leukemia

Explore this box plot interactively →