GMPPB

Across TCGA patient cohorts, GMPPB protein abundance is significantly associated with the RNA expression of many other genes, with 20,642 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GMPPB-associated genes across cancer lineages are GINS3, XBP1, and RAE1. Each is linked with GMPPB in more than 6 cancer types. Because this analysis shows association rather than direction, both GMPPB-to-partner and partner-to-GMPPB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GMPPB versus GINS3 in LSCC, with a Pearson correlation of -0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPPB→partner) and Y-score (partner→GMPPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GINS3 →	-0.640	-0.349	<.001	<.001	3	7
BRCA	XBP1 →	+1.595	+0.317	<.001	<.001	2	7
HNSC	RAE1 →	-0.709	-0.373	<.001	<.001	3	6
HNSC	CSNK2A1 →	-0.500	-0.368	<.001	<.001	3	6
GBM	RTKN →	-0.757	-0.279	<.001	<.001	3	6
HNSC	HERPUD2 →	-0.520	-0.262	.004	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,642 associations by consensus.

GMPPB vs GINS3 — LSCC

Explore this scatter interactively →