GMPPB

Across TCGA patient cohorts, GMPPB mutation is significantly associated with the RNA expression of many other genes, with 654 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMPPB-associated genes across cancer lineages are RNA5SP198, RN7SL254P, and RNA5SP181. Each is linked with GMPPB in more than 2 cancer types. Because this analysis shows association rather than direction, both GMPPB-to-partner and partner-to-GMPPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by GMPPB-low versus GMPPB-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPPB→partner) and Y-score (partner→GMPPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP198 →	+0.374	+6.144	<.001	.001	3	3
COAD	RN7SL254P →	+0.327	+6.392	.001	.001	3	2
STAD	RNA5SP181 →	+0.458	+5.274	.001	.006	3	2
UCEC	RNA5SP405 →	+0.306	+3.260	<.001	.004	3	2
UCEC	RNU6-753P →	+0.147	+4.060	<.001	.006	3	2
UCEC	TRAJ58 →	+0.399	+2.488	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 654 associations by consensus.

RNA5SP198 by GMPPB expression — CESC

Explore this box plot interactively →