GMPPB

Across TCGA patient cohorts, GMPPB mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMPPB-associated genes across cancer lineages are EGFR_pY1068, ERK2, and ACC_pS79. Each is linked with GMPPB in more than 1 cancer types. Because this analysis shows association rather than direction, both GMPPB-to-partner and partner-to-GMPPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GMPPB-low versus GMPPB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPPB→partner) and Y-score (partner→GMPPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.283	-3.169	.012	.019	3	1
UCEC	ERK2 →	+0.253	+3.169	.003	.018	3	1
UCEC	ACC_pS79 →	+0.483	+3.469	.001	.002	3	1
UCEC	GAPDH →	+0.700	+3.807	.003	<.001	3	1
UCEC	GATA6 →	-0.201	-3.321	.005	.010	3	1
UCEC	ACC1 →	+0.367	+2.820	.025	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by GMPPB expression — UCEC

Explore this box plot interactively →