GMPPB

Across TCGA cell cohorts, GMPPB mutation is significantly associated with the mutation status of many other genes, with 1,122 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible GMPPB-associated genes across cancer lineages are FAM20C, LIN54, and SYNC. Each is linked with GMPPB in more than 2 cancer types. Because this analysis shows association rather than direction, both GMPPB-to-partner and partner-to-GMPPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM20C grouped by GMPPB-low versus GMPPB-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPPB→partner) and Y-score (partner→GMPPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FAM20C →	+4.415	+4.977	.007	.007	1	3
OVARY	LIN54 →	+5.415	+5.415	.004	.004	1	3
OVARY	SYNC →	+5.415	+5.415	.004	.004	1	3
OVARY	DDT →	+5.415	+5.415	.004	.004	1	2
OVARY	GGT5 →	+4.415	+4.977	.007	.007	1	2
OVARY	ICAM1 →	+5.415	+5.415	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,122 associations by consensus.

FAM20C by GMPPB expression — OVARY

Explore this box plot interactively →