GMPPA

Across TCGA patient cohorts, GMPPA protein abundance is significantly associated with the RNA expression of many other genes, with 21,881 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GMPPA-associated genes across cancer lineages are XBP1, GMPPB, and BHLHA15. Each is linked with GMPPA in more than 7 cancer types. Because this analysis shows association rather than direction, both GMPPA-to-partner and partner-to-GMPPA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GMPPA versus XBP1 in BRCA, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPPA→partner) and Y-score (partner→GMPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	XBP1 →	+1.968	+0.354	<.001	<.001	3	8
UCEC	GMPPB →	+0.868	+0.210	<.001	.007	3	8
PDAC	BHLHA15 →	+1.719	+0.146	<.001	.002	3	7
HNSC	NASP →	-0.845	-0.355	<.001	<.001	3	7
HNSC	MRPS5 →	-0.448	-0.379	.002	<.001	3	7
LSCC	MEX3A →	-1.246	-0.392	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,881 associations by consensus.

GMPPA vs XBP1 — BRCA

Explore this scatter interactively →