GMPPA

Across TCGA patient cohorts, GMPPA mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMPPA-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1_pT37_T46, and ACC_pS79. Each is linked with GMPPA in more than 1 cancer types. Because this analysis shows association rather than direction, both GMPPA-to-partner and partner-to-GMPPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by GMPPA-low versus GMPPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPPA→partner) and Y-score (partner→GMPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.338	+2.179	.017	.034	3	2
UCEC	4E-BP1_pT37_T46 →	-0.602	-3.446	<.001	.005	3	2
UCEC	ACC_pS79 →	-0.375	-2.115	.013	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.469	+2.817	.035	.036	3	1
UCEC	MSH2 →	-0.331	-3.575	.001	.002	3	1
UCEC	mTOR_pS2448 →	-0.164	-2.446	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p62 Lck ligand by GMPPA expression — UCEC

Explore this box plot interactively →