GMPPA

Across TCGA cell cohorts, GMPPA mutation is significantly associated with the mutation status of many other genes, with 3,438 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GMPPA-associated genes across cancer lineages are PTPRZ1, MYO1A, and ABCC8. Each is linked with GMPPA in more than 5 cancer types. Because this analysis shows association rather than direction, both GMPPA-to-partner and partner-to-GMPPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPRZ1 grouped by GMPPA-low versus GMPPA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMPPA→partner) and Y-score (partner→GMPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PTPRZ1 →	+2.870	+3.347	.009	.009	1	6
LARGE_INTESTINE	MYO1A →	+1.836	+2.906	.009	.009	1	5
BLOOD_Leukemia	ABCC8 →	+2.825	+3.847	.001	.001	1	5
UPPER_AERODIGESTIVE_TRACT	GAA →	+4.392	+4.954	.008	.008	1	5
UPPER_AERODIGESTIVE_TRACT	ADCY5 →	+4.392	+4.954	.008	.008	1	5
LARGE_INTESTINE	PTPN14 →	+2.729	+3.643	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,438 associations by consensus.

PTPRZ1 by GMPPA expression — BLOOD_Leukemia

Explore this box plot interactively →