GMNC

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GMNC mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMNC-associated genes across cancer lineages are NF-kB-p65_pS536, ERK2, and p62 Lck ligand. Each is linked with GMNC in more than 1 cancer types. Because this analysis shows association rather than direction, both GMNC-to-partner and partner-to-GMNC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMNC→partner) and Y-score (partner→GMNC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECNF-kB-p65_pS536 →-0.553-2.990.035.03621
UCECERK2 →+0.262+3.000.018.03711
UCECp62 Lck ligand →+0.507+3.000.007.03711
UCECTIGAR →+0.190+3.026.030.01911
UCECc-Jun_pS73 →-0.192-3.000.036.03711
Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration