GMIP

Across TCGA patient cohorts, GMIP mutation is significantly associated with the RNA expression of many other genes, with 2,819 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMIP-associated genes across cancer lineages are H2AC14, NCAPG, and ELOA. Each is linked with GMIP in more than 2 cancer types. Because this analysis shows association rather than direction, both GMIP-to-partner and partner-to-GMIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AC14 grouped by GMIP-low versus GMIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMIP→partner) and Y-score (partner→GMIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AC14 →	+0.718	+3.098	<.001	<.001	3	3
UCEC	NCAPG →	+0.708	+2.010	<.001	<.001	3	3
UCEC	ELOA →	+0.335	+1.470	.004	.008	3	3
SKCM	BCAS2 →	+0.579	+3.006	.007	<.001	3	3
UCEC	DHDDS →	+0.321	+2.362	.001	<.001	3	3
UCEC	IER3IP1 →	+0.464	+2.375	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,819 associations by consensus.

H2AC14 by GMIP expression — UCEC

Explore this box plot interactively →