GMIP

Across TCGA cell cohorts, GMIP mutation is significantly associated with the RNA expression of many other genes, with 167 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GMIP-associated genes across cancer lineages are C1orf141, OR11H6, and GPX5. Each is linked with GMIP in more than 1 cancer types. Because this analysis shows association rather than direction, both GMIP-to-partner and partner-to-GMIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf141 grouped by GMIP-low versus GMIP-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMIP→partner) and Y-score (partner→GMIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C1orf141 →	+0.049	+5.781	<.001	.001	3	2
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	2
OVARY	GPX5 →	+0.015	+2.643	<.001	.009	3	2
BLOOD_Leukemia	AMELX →	+0.033	+4.539	<.001	.007	3	2
LARGE_INTESTINE	YTHDF2 →	+0.488	+3.299	.002	.004	3	2
BREAST	OR2T5 →	+0.033	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 167 associations by consensus.

C1orf141 by GMIP expression — BREAST

Explore this box plot interactively →