GMFG

Across TCGA pan-cancer cohorts, GMFG mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GMFG data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GMFG mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GMFG expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, COAD, and LSCC are the cancer types where GMFG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.696	0.284	<.001	26	view →
COAD	DFS	Tertile	II,III,IV	0.935	1.000	.040	12	view →
LSCC	DFS	Tertile	All	0.852	0.333	.012	6	view →
HNSC	DFS	Quartile	All	0.898	1.000	.007	5	view →
LUAD	DFS	Median	All	0.771	0.469	.010	4	view →
GBM	DFS	Tertile	All	0.255	0.456	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GMFG–PDAC (OS)

Open the PDAC breakdown →