GMFG

Across TCGA patient cohorts, GMFG mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMFG-associated genes across cancer lineages are CICP15, RNA5SP411, and RNA5SP124. Each is linked with GMFG in more than 1 cancer types. Because this analysis shows association rather than direction, both GMFG-to-partner and partner-to-GMFG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CICP15 grouped by GMFG-low versus GMFG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMFG→partner) and Y-score (partner→GMFG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CICP15 →	+0.010	+3.970	<.001	<.001	3	2
UCEC	RNA5SP411 →	+2.046	+2.978	<.001	.001	3	2
UCEC	RNA5SP124 →	+0.434	+2.581	.001	.007	3	2
UCEC	RNA5SP422 →	+1.185	+2.671	<.001	.005	3	2
CESC	RNY1P1 →	+0.187	+4.757	<.001	.004	3	2
LUSC	RNA5SP424 →	+0.263	+4.724	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

CICP15 by GMFG expression — SKCM

Explore this box plot interactively →