GMFG

Across TCGA patient cohorts, GMFG mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMFG-associated genes across cancer lineages are ATM, Chk2, and INPP4B. Each is linked with GMFG in more than 1 cancer types. Because this analysis shows association rather than direction, both GMFG-to-partner and partner-to-GMFG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GMFG-low versus GMFG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMFG→partner) and Y-score (partner→GMFG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.665	-3.000	.007	.036	3	1
UCEC	Chk2 →	-0.280	-3.169	.029	.019	3	1
UCEC	INPP4B →	-0.417	-3.156	.018	.020	2	1
UCEC	Gab2 →	+0.478	+3.169	.014	.020	1	1
UCEC	MEK1 →	+0.544	+3.169	.006	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ATM by GMFG expression — UCEC

Explore this box plot interactively →