GMFG

Across TCGA cell cohorts, GMFG RNA expression is significantly associated with the go_rna of many other GO terms, with 1,640 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GMFG-associated GO terms across cancer lineages are Regulation of transforming growth factor beta receptor signaling pathway, Regulation of lysosomal membrane permeability, and Response to cocaine. Each is linked with GMFG in more than 5 cancer types. Because this analysis shows association rather than direction, both GMFG-to-partner and partner-to-GMFG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transforming growth factor beta receptor signaling pathway grouped by GMFG-low versus GMFG-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GMFG→partner) and Y-score (partner→GMFG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of transforming growth factor beta receptor signaling pathway →	+0.051	+0.541	<.001	.001	3	6
LUNG_SCLC	Regulation of lysosomal membrane permeability →	-0.143	-0.610	.005	.005	3	6
LUNG_NSCLC_LUSC	Response to cocaine →	+0.139	+0.488	<.001	.003	3	6
SOFT_TISSUE	Negative regulation of molecular function →	+0.049	+1.474	<.001	<.001	3	6
SOFT_TISSUE	Establishment or maintenance of microtubule cytoskeleton polarity →	+0.138	+1.130	<.001	<.001	3	6
LUNG_NSCLC_LUAD	Regulation of ERBB signaling pathway →	+0.054	+0.567	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,640 associations by consensus.

Regulation of transforming growth factor beta receptor signaling pathway by GMFG expression — LUNG_NSCLC_LUSC

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