Across TCGA patient cohorts, GMFB mutation is significantly associated with the RNA expression of many other genes, with 3,279 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMFB-associated genes across cancer lineages are GYG2P1, RNU6-1245P, and RNA5SP67. Each is linked with GMFB in more than 1 cancer types. Because this analysis shows association rather than direction, both GMFB-to-partner and partner-to-GMFB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMFB→partner) and Y-score (partner→GMFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	GYG2P1 →	+0.025	+4.601	.001	.004	3	2
CESC	RNU6-1245P →	+0.414	+5.060	<.001	.001	3	2
CESC	RNA5SP67 →	+0.518	+4.601	<.001	.004	3	2
BLCA	PMS2P8 →	+0.054	+7.640	<.001	.009	3	1
UCEC	NUDT3 →	+0.304	+3.492	.007	.002	3	1
UCEC	POM121C →	+0.502	+2.053	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,279 associations by consensus.

Exploration

GMFB survival (RNA) · tumor vs normal (RNA) · all GMFB data types