Across TCGA patient cohorts, GMFB mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMFB-associated genes across cancer lineages are JNK_pT183_Y185, EGFR_pY1068, and FOXO3a_pS318_S321. Each is linked with GMFB in more than 1 cancer types. Because this analysis shows association rather than direction, both GMFB-to-partner and partner-to-GMFB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMFB→partner) and Y-score (partner→GMFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.184	-2.209	.010	.011	3	2
UCEC	EGFR_pY1068 →	-0.342	-4.000	.001	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.153	-2.449	.003	.019	3	1
UCEC	ACC1 →	+0.315	+2.820	.041	.035	3	1
UCEC	JNK2 →	+0.291	+3.196	<.001	.009	3	1
UCEC	Ku80 →	+0.276	+2.331	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

GMFB survival (RNA) · tumor vs normal (RNA) · all GMFB data types