GMEB2

Across TCGA patient cohorts, GMEB2 mutation is significantly associated with the RNA expression of many other genes, with 2,651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMEB2-associated genes across cancer lineages are SKA1, KPNA6, and TXLNA. Each is linked with GMEB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GMEB2-to-partner and partner-to-GMEB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by GMEB2-low versus GMEB2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMEB2→partner) and Y-score (partner→GMEB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SKA1 →	+0.727	+2.598	<.001	.006	3	3
UCEC	KPNA6 →	+0.519	+2.439	.002	.001	3	3
UCEC	TXLNA →	+0.373	+3.939	.001	<.001	3	3
UCEC	PARP2 →	+0.406	+2.662	.005	<.001	3	3
COAD	VCL →	+0.649	+3.200	<.001	.009	3	3
GBM	MIR5583-1 →	+0.823	+7.209	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,651 associations by consensus.

SKA1 by GMEB2 expression — COAD

Explore this box plot interactively →