GMEB2

Across TCGA cell cohorts, GMEB2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GMEB2-associated genes across cancer lineages are ZNF705G, RESP18, and KRTAP20-2. Each is linked with GMEB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GMEB2-to-partner and partner-to-GMEB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF705G grouped by GMEB2-low versus GMEB2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMEB2→partner) and Y-score (partner→GMEB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF705G →	+0.032	+4.467	<.001	.004	3	1
OVARY	RESP18 →	+0.045	+5.196	<.001	.005	3	1
OVARY	KRTAP20-2 →	+0.117	+5.196	<.001	.005	3	1
OVARY	DAZ2 →	+0.106	+5.807	<.001	.001	3	1
OVARY	CT47A6 →	+0.030	+5.807	<.001	.001	3	1
LARGE_INTESTINE	LILRA1 →	+0.009	+3.510	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ZNF705G by GMEB2 expression — SKIN

Explore this box plot interactively →