GMDS

Across TCGA pan-cancer cohorts, GMDS mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GMDS data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GMDS mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GMDS expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where GMDS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.650	0.403	<.001	74	view →
CCRCC	DFS	Tertile	All	0.931	0.674	<.001	50	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.431	.018	12	view →
LUAD	OS	Quartile	II,III,IV	0.433	0.892	.029	8	view →
HNSC	OS	Tertile	II,III,IV	0.948	1.000	.039	3	view →
GBM	OS	Median	All	0.287	0.466	.049	2	view →
LSCC	OS	Median	III,IV	0.910	0.576	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GMDS–PDAC (OS)

Open the PDAC breakdown →