GMDS

Across TCGA patient cohorts, GMDS RNA expression is significantly associated with the protein abundance of many other proteins, with 13,027 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMDS-associated proteins across cancer lineages are GMDS_S14, FOXA1_S331, and CARMIL1. Each is linked with GMDS in more than 5 cancer types. Because this analysis shows association rather than direction, both GMDS-to-partner and partner-to-GMDS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GMDS versus GMDS_S14 in PDAC, with a Pearson correlation of 0.70.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GMDS→partner) and Y-score (partner→GMDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GMDS_S14 →	+0.864	+0.987	<.001	<.001	3	6
UCEC	FOXA1_S331 →	+1.239	+0.653	<.001	.003	3	5
OV	CARMIL1 →	+0.561	+0.774	<.001	<.001	3	4
OV	IAH1 →	-0.368	-0.560	.003	.004	3	4
LSCC	PRPF4B_S277 →	+0.346	+0.348	<.001	.004	3	4
BRCA	BAG3 →	-0.450	-0.553	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,027 associations by consensus.

GMDS vs GMDS_S14 — PDAC

Explore this scatter interactively →