GMDS

Across TCGA patient cohorts, GMDS protein abundance is significantly associated with the RNA expression of many other genes, with 17,677 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GMDS-associated genes across cancer lineages are SMIM31, TSPAN1, and RNF183. Each is linked with GMDS in more than 6 cancer types. Because this analysis shows association rather than direction, both GMDS-to-partner and partner-to-GMDS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GMDS versus SMIM31 in LUAD, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMDS→partner) and Y-score (partner→GMDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SMIM31 →	+1.190	+0.409	<.001	<.001	3	7
HNSC	TSPAN1 →	+1.453	+0.404	<.001	<.001	3	6
UCEC	RNF183 →	+1.386	+0.488	<.001	<.001	3	6
UCEC	C9orf152 →	+1.694	+0.769	<.001	<.001	3	6
UCEC	CERS5 →	-0.365	-0.502	<.001	<.001	3	6
LSCC	TMC5 →	+1.337	+0.376	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,677 associations by consensus.

GMDS vs SMIM31 — LUAD

Explore this scatter interactively →