GMDS

Across TCGA patient cohorts, GMDS mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMDS-associated genes across cancer lineages are p21, VHL, and Di-Ras3. Each is linked with GMDS in more than 1 cancer types. Because this analysis shows association rather than direction, both GMDS-to-partner and partner-to-GMDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by GMDS-low versus GMDS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMDS→partner) and Y-score (partner→GMDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.243	+3.169	.021	.020	3	1
UCEC	VHL →	-0.940	-3.169	.011	.019	3	1
UCEC	Di-Ras3 →	-0.188	-3.169	.021	.020	2	2
UCEC	Tuberin →	+0.364	+3.169	.013	.020	1	1
UCEC	Cyclin-B1 →	+0.934	+3.169	.002	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p21 by GMDS expression — UCEC

Explore this box plot interactively →