GMDS

Across TCGA cell cohorts, GMDS mutation is significantly associated with the RNA expression of many other genes, with 180 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GMDS-associated genes across cancer lineages are C12orf40, PNLIPRP1, and TFDP3. Each is linked with GMDS in more than 1 cancer types. Because this analysis shows association rather than direction, both GMDS-to-partner and partner-to-GMDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by GMDS-low versus GMDS-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMDS→partner) and Y-score (partner→GMDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
OVARY	PNLIPRP1 →	+0.029	+4.450	<.001	.004	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.283	+3.196	<.001	.007	3	1
BLOOD_Leukemia	CERK →	+0.888	+3.199	.006	.007	3	1
BLOOD_Leukemia	SLC32A1 →	+0.423	+2.486	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

C12orf40 by GMDS expression — OVARY

Explore this box plot interactively →