GMCL2

Across TCGA patient cohorts, GMCL2 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMCL2-associated genes across cancer lineages are INPP4B, MEK1, and STAT3_pY705. Each is linked with GMCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GMCL2-to-partner and partner-to-GMCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by GMCL2-low versus GMCL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMCL2→partner) and Y-score (partner→GMCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.327	-3.000	.044	.036	3	1
UCEC	MEK1 →	+0.479	+3.169	.009	.019	3	1
UCEC	STAT3_pY705 →	-0.455	-2.321	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

INPP4B by GMCL2 expression — UCEC

Explore this box plot interactively →