GMCL1

Across TCGA patient cohorts, GMCL1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMCL1-associated genes across cancer lineages are EGFR_pY1068, FASN, and ACVRL1. Each is linked with GMCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GMCL1-to-partner and partner-to-GMCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GMCL1-low versus GMCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMCL1→partner) and Y-score (partner→GMCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.243	-3.169	.026	.018	3	1
UCEC	FASN →	+0.382	+2.115	.026	.019	3	1
UCEC	ACVRL1 →	-0.159	-3.156	.007	.018	3	1
UCEC	Ku80 →	+0.208	+1.598	.044	.044	3	1
UCEC	MEK1 →	+0.406	+2.115	.011	.019	3	1
UCEC	p62 Lck ligand →	+0.444	+3.169	.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by GMCL1 expression — UCEC

Explore this box plot interactively →