Across TCGA patient cohorts, GM2A protein abundance is significantly associated with the RNA expression of many other genes, with 11,884 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GM2A-associated genes across cancer lineages are APOC1, TMEM86A, and TMEM273. Each is linked with GM2A in more than 4 cancer types. Because this analysis shows association rather than direction, both GM2A-to-partner and partner-to-GM2A results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GM2A→partner) and Y-score (partner→GM2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	APOC1 →	+1.316	+0.479	<.001	<.001	3	5
HNSC	TMEM86A →	+1.136	+0.555	<.001	<.001	3	5
UCEC	TMEM273 →	+0.618	+0.440	.002	<.001	3	5
UCEC	CD84 →	+0.859	+0.409	.005	.009	3	5
UCEC	LIPA →	+0.729	+0.487	<.001	<.001	3	5
CCRCC	CHIT1 →	+1.367	+0.370	.005	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,884 associations by consensus.

Exploration

GM2A survival (RNA) · tumor vs normal (RNA) · all GM2A data types