GLYR1

Across TCGA patient cohorts, GLYR1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLYR1-associated genes across cancer lineages are GAPDH, eEF2, and eIF4E. Each is linked with GLYR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLYR1-to-partner and partner-to-GLYR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by GLYR1-low versus GLYR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLYR1→partner) and Y-score (partner→GLYR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.454	+2.115	.024	.017	3	3
UCEC	eEF2 →	+0.393	+2.584	.003	.010	3	2
UCEC	eIF4E →	+0.233	+3.700	.003	.001	3	2
UCEC	EGFR_pY1068 →	-0.206	-1.765	.028	.014	3	1
UCEC	ERK2 →	+0.194	+2.169	.007	.003	3	1
UCEC	FOXO3a_pS318_S321 →	-0.098	-1.797	.036	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

GAPDH by GLYR1 expression — UCEC

Explore this box plot interactively →