GLYCTK

Across TCGA patient cohorts, GLYCTK mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLYCTK-associated genes across cancer lineages are Fibronectin, Notch1, and JNK2. Each is linked with GLYCTK in more than 1 cancer types. Because this analysis shows association rather than direction, both GLYCTK-to-partner and partner-to-GLYCTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by GLYCTK-low versus GLYCTK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLYCTK→partner) and Y-score (partner→GLYCTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.337	-2.459	.034	.020	3	2
UCEC	Notch1 →	+0.151	+2.459	.026	.020	3	2
UCEC	JNK2 →	+0.264	+2.459	.005	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.453	-2.459	.046	.020	3	1
UCEC	PDK1_pS241 →	+0.180	+3.321	.029	.010	3	1
UCEC	AMPK_pT172 →	+0.489	+2.472	.013	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Fibronectin by GLYCTK expression — UCEC

Explore this box plot interactively →