GLYATL2

Across TCGA patient cohorts, GLYATL2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLYATL2-associated genes across cancer lineages are TFRC, MEK1, and p38-MAPK_pT180_Y182. Each is linked with GLYATL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLYATL2-to-partner and partner-to-GLYATL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by GLYATL2-low versus GLYATL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLYATL2→partner) and Y-score (partner→GLYATL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.661	+2.584	.001	.001	3	3
UCEC	MEK1 →	+0.536	+4.321	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.354	-1.807	.040	.025	3	2
UCEC	p62 Lck ligand →	+0.437	+2.584	<.001	.001	3	2
UCEC	PCNA →	+0.192	+2.459	.020	.018	3	2
UCEC	VHL →	-1.144	-2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

TFRC by GLYATL2 expression — UCEC

Explore this box plot interactively →