GLYATL1

Across TCGA patient cohorts, GLYATL1 mutation is significantly associated with the RNA expression of many other genes, with 2,167 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLYATL1-associated genes across cancer lineages are IFRD2, GPIHBP1, and CENPU. Each is linked with GLYATL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLYATL1-to-partner and partner-to-GLYATL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFRD2 grouped by GLYATL1-low versus GLYATL1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLYATL1→partner) and Y-score (partner→GLYATL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IFRD2 →	+0.282	+2.636	.006	<.001	3	3
UCEC	GPIHBP1 →	-0.423	-2.321	.008	.006	3	2
UCEC	CENPU →	+0.748	+3.502	.002	.002	3	2
UCEC	FARP1 →	+0.560	+2.332	.001	.003	3	2
UCEC	DPH3 →	+0.425	+2.740	.007	.003	3	2
UCEC	PKN3 →	+0.759	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,167 associations by consensus.

IFRD2 by GLYATL1 expression — SKCM

Explore this box plot interactively →