GLYAT

Across TCGA patient cohorts, GLYAT mutation is significantly associated with the RNA expression of many other genes, with 2,432 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLYAT-associated genes across cancer lineages are SF3B2, GARS1, and CCDC86. Each is linked with GLYAT in more than 3 cancer types. Because this analysis shows association rather than direction, both GLYAT-to-partner and partner-to-GLYAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF3B2 grouped by GLYAT-low versus GLYAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLYAT→partner) and Y-score (partner→GLYAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SF3B2 →	+0.452	+2.425	.001	.002	3	4
SKCM	GARS1 →	+0.452	+3.649	.001	.001	3	3
UCEC	CCDC86 →	+0.521	+3.119	.004	<.001	3	3
SKCM	PPM1G →	+0.286	+2.816	.007	.001	3	3
UCEC	FARSB →	+0.408	+2.415	.002	.003	3	3
UCEC	EIF2S2 →	+0.586	+3.098	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,432 associations by consensus.

SF3B2 by GLYAT expression — UCEC

Explore this box plot interactively →