GLYAT

Across TCGA cell cohorts, GLYAT RNA expression is significantly associated with the go_rna of many other GO terms, with 1,317 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GLYAT-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Positive regulation of intracellular estrogen receptor signaling pathway, and Regulation of protein K48-linked ubiquitination. Each is linked with GLYAT in more than 5 cancer types. Because this analysis shows association rather than direction, both GLYAT-to-partner and partner-to-GLYAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by GLYAT-low versus GLYAT-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GLYAT→partner) and Y-score (partner→GLYAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of alternative mRNA splicing, via spliceosome →	+0.057	+0.065	<.001	.002	3	6
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.229	+0.281	<.001	.002	3	5
KIDNEY	Regulation of protein K48-linked ubiquitination →	+0.126	+0.113	<.001	<.001	2	6
KIDNEY	Regulation of pattern recognition receptor signaling pathway →	+0.056	+0.112	<.001	<.001	2	6
SOFT_TISSUE	Positive regulation of T cell mediated cytotoxicity →	+0.117	+0.025	.006	.003	3	4
BONE	Regulation of mRNA processing →	+0.089	+0.245	.004	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,317 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by GLYAT expression — BLOOD_Lymphoma

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