GLUL

Across TCGA patient cohorts, GLUL mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLUL-associated genes across cancer lineages are eIF4E, MEK1, and MSH6. Each is linked with GLUL in more than 1 cancer types. Because this analysis shows association rather than direction, both GLUL-to-partner and partner-to-GLUL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GLUL-low versus GLUL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLUL→partner) and Y-score (partner→GLUL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.182	+3.584	.024	.002	3	2
UCEC	MEK1 →	+0.375	+2.115	.007	.017	3	2
UCEC	MSH6 →	-0.393	-3.321	.001	.009	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.434	-2.999	.011	.035	3	2
UCEC	PDK1 →	+0.105	+2.335	.011	.018	3	2
UCEC	Rad50 →	-0.329	-2.087	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eIF4E by GLUL expression — UCEC

Explore this box plot interactively →