GLTP

Across TCGA patient cohorts, GLTP mutation is significantly associated with the RNA expression of many other genes, with 446 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLTP-associated genes across cancer lineages are RNA5SP146, TAF9, and MIR6515. Each is linked with GLTP in more than 1 cancer types. Because this analysis shows association rather than direction, both GLTP-to-partner and partner-to-GLTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP146 grouped by GLTP-low versus GLTP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLTP→partner) and Y-score (partner→GLTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP146 →	+0.355	+3.302	<.001	<.001	3	2
UCEC	TAF9 →	+0.782	+3.191	<.001	.009	3	1
UCEC	MIR6515 →	+0.310	+3.598	<.001	.002	3	1
UCEC	AATF →	+0.567	+3.584	.001	.003	3	1
UCEC	PIGW →	+0.665	+3.595	.004	.001	3	1
UCEC	EIF3M →	+0.645	+3.617	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 446 associations by consensus.

RNA5SP146 by GLTP expression — UCEC

Explore this box plot interactively →