GLTP

Across TCGA patient cohorts, GLTP mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLTP-associated genes across cancer lineages are p62 Lck ligand, Caspase-7-cleavedD198, and Caspase-8. Each is linked with GLTP in more than 1 cancer types. Because this analysis shows association rather than direction, both GLTP-to-partner and partner-to-GLTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by GLTP-low versus GLTP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLTP→partner) and Y-score (partner→GLTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.408	+3.009	.022	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+1.402	+3.189	<.001	.010	3	1
UCEC	Caspase-8 →	-0.285	-2.973	.038	.035	3	1
UCEC	PCNA →	+0.409	+3.169	<.001	.020	2	1
UCEC	EGFR →	-0.194	-3.169	.027	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p62 Lck ligand by GLTP expression — UCEC

Explore this box plot interactively →