GLS2

Across TCGA pan-cancer cohorts, GLS2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GLS2 data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher GLS2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GLS2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

MESO, BLCA, and UCEC are the cancer types where GLS2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	II,III,IV	0.039	0.407	<.001	12	view →
BLCA	OS	Median	III,IV	0.183	0.684	.004	9	view →
UCEC	DFS	Median	All	0.959	0.619	.016	8	view →
CESC	DFS	Median	II,III,IV	0.146	0.705	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GLS2–MESO (DFS)

Open the MESO breakdown →