GLS2

Across TCGA cell cohorts, GLS2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLS2-associated genes across cancer lineages are FSHB, SH3GL2, and TAFA1. Each is linked with GLS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLS2-to-partner and partner-to-GLS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHB grouped by GLS2-low versus GLS2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLS2→partner) and Y-score (partner→GLS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FSHB →	+0.032	+5.321	<.001	.005	3	1
LARGE_INTESTINE	SH3GL2 →	+1.091	+3.252	.006	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	ELOA3DP →	+0.019	+2.688	<.001	.008	3	1
LARGE_INTESTINE	BPIFA1 →	+0.109	+3.425	.003	<.001	3	1
LARGE_INTESTINE	SLC39A12 →	+0.062	+3.285	.002	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FSHB by GLS2 expression — CNS

Explore this box plot interactively →