GLRX3

Across TCGA patient cohorts, GLRX3 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLRX3-associated genes across cancer lineages are MEK1, Notch1, and ATM. Each is linked with GLRX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLRX3-to-partner and partner-to-GLRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GLRX3-low versus GLRX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRX3→partner) and Y-score (partner→GLRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.334	+2.321	.031	.034	3	2
UCEC	Notch1 →	+0.125	+2.183	.036	.033	3	2
UCEC	ATM →	-0.704	-2.222	<.001	.011	3	2
UCEC	C-Raf →	+0.169	+2.321	.005	.033	3	2
UCEC	eIF4E →	+0.184	+2.321	.039	.034	3	1
UCEC	JNK2 →	+0.190	+1.700	.024	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MEK1 by GLRX3 expression — UCEC

Explore this box plot interactively →