GLRX2

Across TCGA patient cohorts, GLRX2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLRX2-associated genes across cancer lineages are ACVRL1, Myosin-IIa_pS1943, and Notch1. Each is linked with GLRX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLRX2-to-partner and partner-to-GLRX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by GLRX2-low versus GLRX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRX2→partner) and Y-score (partner→GLRX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.143	-2.302	.029	.034	3	1
UCEC	Myosin-IIa_pS1943 →	+0.210	+2.472	.035	.011	3	1
UCEC	Notch1 →	+0.201	+2.459	.003	.020	3	1
UCEC	p90 RSK →	+0.186	+3.009	.044	.019	3	1
UCEC	Tuberin_pT1462 →	+0.323	+2.459	.003	.020	3	1
UCEC	Tuberin →	+0.419	+2.999	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ACVRL1 by GLRX2 expression — UCEC

Explore this box plot interactively →