GLRA3

Across TCGA patient cohorts, GLRA3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLRA3-associated genes across cancer lineages are Cyclin-B1, MEK1, and p38-MAPK_pT180_Y182. Each is linked with GLRA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLRA3-to-partner and partner-to-GLRA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by GLRA3-low versus GLRA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRA3→partner) and Y-score (partner→GLRA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.452	+1.440	.020	.024	3	3
UCEC	MEK1 →	+0.307	+2.087	.015	.005	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.385	-3.442	.002	.004	3	2
UCEC	14-3-3_beta →	-0.103	-3.673	.003	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.143	-1.723	.014	.007	3	2
UCEC	p62 Lck ligand →	+0.395	+3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Cyclin-B1 by GLRA3 expression — UCEC

Explore this box plot interactively →