GLRA1

Across TCGA patient cohorts, GLRA1 mutation is significantly associated with the RNA expression of many other genes, with 2,164 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLRA1-associated genes across cancer lineages are RNASEH2A, CEP89, and POC1A. Each is linked with GLRA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLRA1-to-partner and partner-to-GLRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASEH2A grouped by GLRA1-low versus GLRA1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRA1→partner) and Y-score (partner→GLRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNASEH2A →	+0.582	+2.207	<.001	.001	3	3
SKCM	CEP89 →	+0.446	+2.140	<.001	.009	3	3
UCEC	POC1A →	+0.647	+2.923	.001	<.001	3	3
SKCM	CELSR3 →	+0.730	+3.385	<.001	.004	3	3
HNSC	RNU6-847P →	+0.366	+5.339	<.001	.003	3	3
UCEC	SKA1 →	+0.821	+2.673	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,164 associations by consensus.

RNASEH2A by GLRA1 expression — SKCM

Explore this box plot interactively →