GLRA1

Across TCGA patient cohorts, GLRA1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLRA1-associated genes across cancer lineages are STAT3_pY705, Cyclin-B1, and ERK2. Each is linked with GLRA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GLRA1-to-partner and partner-to-GLRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by GLRA1-low versus GLRA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRA1→partner) and Y-score (partner→GLRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.562	-3.169	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.674	+2.584	.002	.010	3	3
SKCM	ERK2 →	+0.218	+2.700	.014	.005	3	2
UCEC	FoxM1 →	+0.208	+1.584	.041	.036	3	2
UCEC	Notch1 →	+0.139	+2.469	.011	.010	3	2
UCEC	PCNA →	+0.316	+3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

STAT3_pY705 by GLRA1 expression — UCEC

Explore this box plot interactively →