GLRA1

Across TCGA cell cohorts, GLRA1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GLRA1-associated genes across cancer lineages are LALBA, GBX1, and TPPP2. Each is linked with GLRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLRA1-to-partner and partner-to-GLRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LALBA grouped by GLRA1-low versus GLRA1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLRA1→partner) and Y-score (partner→GLRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LALBA →	+0.050	+5.754	<.001	.002	3	1
SKIN	GBX1 →	+0.101	+3.845	.007	.003	3	1
SKIN	TPPP2 →	+0.034	+3.632	.003	.003	3	1
LARGE_INTESTINE	ADAM2 →	+0.094	+4.217	.002	.001	3	1
LARGE_INTESTINE	KIF2B →	+0.010	+4.437	<.001	.004	3	1
LARGE_INTESTINE	FCRL4 →	+0.019	+4.510	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

LALBA by GLRA1 expression — CNS

Explore this box plot interactively →