GLOD5

Across TCGA patient cohorts, GLOD5 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GLOD5-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and Cyclin-B1. Each is linked with GLOD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GLOD5-to-partner and partner-to-GLOD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GLOD5-low versus GLOD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GLOD5→partner) and Y-score (partner→GLOD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.338	-3.321	.010	.010	3	1
UCEC	A-Raf_pS299 →	-0.136	-3.000	.029	.036	3	1
UCEC	Cyclin-B1 →	+0.683	+3.321	.020	.010	3	1
UCEC	VEGFR2 →	+0.368	+3.335	.018	.005	2	1
UCEC	Caspase-7-cleavedD198 →	+0.928	+2.827	.002	.035	2	1
UCEC	Caspase-8 →	-0.306	-3.000	.020	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1068 by GLOD5 expression — UCEC

Explore this box plot interactively →